Bernhard H F Weber Selected Research

Vitelliform Macular Dystrophy

2/2020	Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies.
7/2019	The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
1/2018	BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes.
2/2008	Molecular evolution and functional divergence of the bestrophin protein family.
1/2007	Insertion and topology of normal and mutant bestrophin-1 in the endoplasmic reticulum membrane.
4/2002	Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Bernhard H F Weber Research Topics

Disease

31	Macular Degeneration (Age-Related Maculopathy) 05/2022 - 11/2005
12	Retinoschisis (Retinoschisis, Juvenile) 01/2019 - 04/2002
8	Neoplasms (Cancer) 01/2018 - 08/2006
6	Choroidal Neovascularization 10/2020 - 07/2009
6	Vitelliform Macular Dystrophy 02/2020 - 04/2002
6	Disease Progression 10/2016 - 07/2006
6	Glaucoma 12/2015 - 04/2008
5	Geographic Atrophy 01/2020 - 01/2014
5	Stargardt Disease 01/2019 - 07/2007
5	Inflammation (Inflammations) 01/2018 - 07/2007
5	Breast Neoplasms (Breast Cancer) 06/2010 - 11/2006
4	Ischemia 11/2019 - 01/2016
4	Retinal Diseases 11/2019 - 12/2003
4	Atrophy 10/2016 - 11/2011
4	Familial Breast Cancer 06/2007 - 08/2006
3	Vitreoretinochoroidopathy 02/2020 - 01/2016
3	Macular Edema 07/2017 - 03/2002
3	Open-Angle Glaucoma (Glaucoma, Open Angle) 12/2015 - 10/2009
3	Blindness (Hysterical Blindness) 10/2011 - 07/2007
3	Retinitis Pigmentosa (Pigmentary Retinopathy) 09/2010 - 08/2002
2	Bestrophinopathy 02/2020 - 01/2018
2	Eye Diseases (Eye Disease) 01/2020 - 01/2020
2	Gliosis 02/2019 - 01/2014
2	Retinal Dystrophies 01/2019 - 05/2009
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 01/2018
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 01/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 11/2015
2	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 10/2010
2	Ovarian Neoplasms (Ovarian Cancer) 01/2018 - 07/2006
2	congenital stationary Night blindness 04/2016 - 08/2002
2	Ocular Hypertension (Glaucoma, Suspect) 12/2015 - 01/2014
2	Low Tension Glaucoma 12/2015 - 01/2014
2	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 12/2015 - 01/2014
2	Retinal Degeneration 01/2014 - 09/2009
2	Exfoliation Syndrome 02/2011 - 10/2010
2	Huntington Disease (Huntington's Disease) 03/2006 - 05/2002
1	Endophthalmitis (Ophthalmia) 01/2020
1	Triple Negative Breast Neoplasms 01/2018
1	Atypical Hemolytic Uremic Syndrome 01/2018
1	Autoimmune Diseases (Autoimmune Disease) 01/2017
1	Skin Neoplasms (Skin Cancer) 01/2017
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 04/2016
1	Genetic Risk Score 01/2016
1	Migraine Disorders (Migraine) 12/2015
1	Chronic Disease (Chronic Diseases) 10/2015
1	Infertility (Sterility) 05/2015
1	Rheumatoid Arthritis 03/2015
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2015
1	Neuroinflammatory Diseases 01/2014
1	Rheumatic Diseases (Rheumatism) 01/2014

Drug/Important Bio-Agent (IBA)

23	Retinaldehyde (Retinal)IBA 01/2020 - 04/2002
11	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2002
9	Complement Factor H (Factor H)IBA 01/2018 - 11/2005
8	Complement System Proteins (Complement)IBA 11/2019 - 07/2007
6	BestrophinsIBA 02/2020 - 01/2007
5	MicroRNAs (MicroRNA)IBA 01/2017 - 01/2009
4	Complement C3 (C3 Complement)IBA 01/2020 - 10/2009
4	Amino Acids FDA Link 04/2007 - 08/2006
3	LigandsIBA 02/2019 - 10/2009
3	Estrogen ReceptorsIBA 01/2018 - 11/2006
3	dorzolamide (Trusopt)FDA LinkGeneric 07/2017 - 09/2012
3	Messenger RNA (mRNA)IBA 04/2011 - 07/2008
2	Circulating MicroRNAIBA 04/2020 - 01/2014
2	Mutant Proteins (Protein, Mutant)IBA 07/2019 - 01/2018
2	NucleotidesIBA 01/2018 - 07/2006
2	Oxygen (Dioxygen)IBA 01/2017 - 04/2016
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2017 - 04/2012
2	Biomarkers (Surrogate Marker)IBA 10/2016 - 01/2014
2	Therapeutic UsesIBA 10/2016 - 09/2012
2	hydroxide ionIBA 12/2015 - 01/2014
2	Apolipoproteins E (ApoE)IBA 12/2011 - 10/2010
2	ApolipoproteinsIBA 10/2010 - 07/2009
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2022
1	hyaluronate lyase (spreading factor)IBA 12/2020
1	VitronectinIBA 12/2020
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 10/2020
1	AnionsIBA 02/2020
1	pegcetacoplanIBA 01/2020
1	N- benzyl- N- ethyl- 2- (7,8- dihydro- 7- methyl- 8- oxo- 2- phenyl- 9H- purin- 9- yl)acetamideIBA 02/2019
1	Antisense OligonucleotidesIBA 01/2019
1	CholesterolIBA 12/2018
1	ErbB Receptors (EGF Receptor)IBA 01/2018
1	CeramidesIBA 01/2018
1	human ERBB2 proteinIBA 01/2018
1	SphingolipidsIBA 01/2018
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2018
1	Mitogen-Activated Protein KinasesIBA 01/2017
1	oxidized low density lipoproteinIBA 01/2017
1	Complement C4aIBA 04/2016
1	poly(dG-dA)n.poly(dC-dT)n (((GA)n))IBA 01/2016
1	Serine Proteases (Serine Protease)IBA 11/2015
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 03/2015
1	Chloroquine (Aralen)FDA LinkGeneric 03/2015
1	Complement Factor D (Factor D)IBA 02/2014
1	Monoclonal AntibodiesIBA 02/2014
1	lampalizumabIBA 02/2014
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2014

Therapy/Procedure

7	Therapeutics 08/2019 - 11/2006
3	Lasers (Laser) 04/2020 - 07/2007
1	Transcutaneous Electric Nerve Stimulation (TENS) 05/2022